Depressed Metabolism

Sometime in the 1780s the French scientist Jacques Charles’s noted that  at constant pressure, the volume of a given mass of an ideal gas increases or decreases by the same factor as its temperature on the absolute temperature scale. Or, put more simply, the gas expands as the temperature increases. This is known [...]

This is the seventh entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. After spending a few years on perfecting on Andjus’ technique for resuscitating rodents (rats and hamsters) from ultraprofound hypothermic and high subzero temperatures, Audrey Smith upped the ante and attempted the same [...]

This is the sixth entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. After successfully reanimating rats from deep body temperatures of 0 – 2 degrees C and subsequent respiratory and cardiac arrest, Andjus allowed the survivors to live for many months afterward in order [...]

This is the fifth entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. As we have seen, Radoslav Andjus had determined a method for achieving excellent (75-100%) recovery rates in rats cooled to 0-2 degrees C by local cardiac heating prior to warming the whole [...]

This is the fourth entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. Up to this point we have discussed the groundbreaking research in the early 1950s performed by Radoslav Andjus in resuscitating rats from body temperatures between 0 and 2 degrees C. Having determined [...]

This is the third entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. Andjus and Smith were delighted that they had managed to modify Andjus’ chest-wall heating technique from using a hot metal spatula to using a focused beam of light in order to preferentially [...]

This is the second entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. As discussed previously, in 1951 Radoslav Andjus developed a simple method for resuscitating rats cooled to deep body temperatures between 0 and 2 degrees C which involved applying a hot spatula to [...]

This is the first entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. Prior work in hypothermia began in the early 1900s, but because cardiac and respiratory arrest were observed in the animals around 15 degrees C, researchers assumed they were irreversibly dead [...]