Depressed Metabolism

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This is the sixth entry in a series about resuscitation of non-hibernating rodents from circulatory arrest at ultraprofound hypothermic and high subzero temperatures. After successfully reanimating rats from deep body temperatures of 0 – 2 degrees C and subsequent respiratory and cardiac arrest, Andjus allowed the survivors to live for many months afterward in order [...]

Because the current generation of vitrification agents permit cryopreservation of the brain without ice formation, the current objective of cryonics research is maintenance of viability of the brain during cryopreservation. The most popular viability assay that has been used in cryonics and cryonics-associated cryobiology research is the potassium/sodium ratio (K+/Na+ ratio). Because the ability [...]

An ongoing quest in cryonics is the successful demonstration of memory sustainment after cryopreservation of the brain and rewarming from cryogenic temperatures. To that end, landmark experiments were performed by Pichugin, et al. (2006) on rat hippocampal brain slices which indicate that the hippocampus retains excellent structural integrity and viability (as measured by Na+/K+ ion [...]