Depressed Metabolism

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In his article entitled ‘Evidence Based Cryonics’ Aschwin de Wolf unassailably argues that: “There is an urgent need to move from extrapolation based cryonics to evidence based cryonics. This will require a comprehensive research program aimed at creating realistic cryonics research models. It will also require vast improvements in the monitoring and evaluation of cryonics [...]

Cryonics patients can greatly benefit from rapid stabilization after pronouncement of legal death. One fortunate feature of stabilization procedures is that the most effective and validated procedures are relatively inexpensive and easy to perform.  The difference between no stabilization procedures at all and procedures that aim to rapidly restore blood circulation and drop the patient’s [...]

It has been shown that perfusability of the brain is significantly compromised after long-term (>5 min) ischemic events (the “no reflow” phenomenon). Improving cerebral blood flow after circulatory arrest is one of the fundamental objectives of human cryopreservation stabilization protocol.  To that end, cryonics organizations administer the resuscitation fluid Dextran-40 and the drug Streptokinase to [...]

Experiments investigating the effects of medication administration via the nose are becoming increasingly common in scientific literature. Direct olfactory transport to the brain and the consequent lack of systemic side effects make nasal administration of neuroactive drugs a very attractive option for doctors and patients alike.
Neuropeptides such as insulin and melanocortins are known to play [...]

A comprehensive review of cryonics stabilization medications is now published on the Alcor website.
Table of contents:
* Introduction
* General Anesthesia
* Blood Coagulation
* Vasoactive Medications
* Excitotoxity
* Free Radicals
* Nitric Oxide and PARP
* Inflammation
* Antibiotics
* Acidosis
* Hemodilution and Osmotic Therapy
* Coenzyme Q10
* Magnesium
* Na+ /H+ Exchange Inhibition
* Immunosuppressive Drugs
* Gastrointestinal Ischemia
* Depressed Metabolism
* Combining Medications
* Conclusion