Tag Archives: Ischemia

Medico-Legal Aspects of Human Cryopreservation Optimization

Posted on May 28, 2011 by Aschwin de Wolf

Introduction Ongoing legal challenges and hostile interference of relatives have increased awareness among cryonicists that addressing the likelihood that one will be cryopreserved at all should take center stage among other strategies for survival. As a consequence, a number of … Continue reading →

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The RhinoChill: A New Way to Cool the Brain Quickly

Posted on January 20, 2011 by Mike Darwin

We scientists are difficult, cranky, and above all, maddeningly frustrating people. Want to turn lead into gold? No problem, we can tell you how to do that, and in fact have even done it already: the only catch is that … Continue reading →

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Chemical preservation and cryonics research

Posted on July 22, 2010 by Aschwin de Wolf

In the 2009-4 issue of Alcor’s Cryonics magazine I review the technical and practical feasibility of chemical preservation. One of the most interesting aspects of chemopreservation is that it could play a useful role in the cryopreservation of ischemic patients. … Continue reading →

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Reversible cryopreservation

Posted on October 1, 2009 by Aschwin de Wolf

On the forum of the Immortality Institute there is an interesting exchange about the feasibility and time line for reversible cryopreservation. Cryobiologist Brian Wowk weighs in with some interesting observations: I think in the next 20 years more small animal … Continue reading →

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PLAC blood test for sudden cardiac arrest and stroke risk

Posted on October 9, 2008 by Chana de Wolf

Life Extension Foundation (LEF) unveiled a new blood test in an article in this month’s Life Extension Magazine (November 2008). Unlike cholesterol testing, which simply gives a measurement of high-density (HDL) and low-density (LDL) lipoprotein levels and provides little information … Continue reading →

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Dietary supplements induce neurogenesis after stroke

Posted on August 20, 2008 by Aschwin de Wolf

A recent study in Rejuvenation Research reports that a combination of dietary supplements confer neuroprotection in stroke. Over a 2 week period rats received either a proprietary formulation of blueberry, green tea, Vitamin D3, and carnosine  called NT-020 or vehicle … Continue reading →

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Cerebral blood flow during and after cardiac arrest

Posted on June 27, 2008 by Chana de Wolf

As discussed in a previous post, perfusion of the brain following long-term (>5 min) ischemia has been shown to be significantly compromised, particularly in subcortical regions. An interesting recent article by Ristagno, et. al in Resuscitation (May 2008) has added … Continue reading →

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Intranasal administration of medications

Posted on June 7, 2008 by Chana de Wolf

Experiments investigating the effects of medication administration via the nose are becoming increasingly common in scientific literature. Direct olfactory transport to the brain and the consequent lack of systemic side effects make nasal administration of neuroactive drugs a very attractive … Continue reading →

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Neuroprotection for ischemic stroke

Posted on April 17, 2008 by Aschwin de Wolf

The journal Neuropharmacology recently published a new review of the current state of the art in neuroprotection for ischemic stroke. A strict definition of a neuroprotectant excludes agents that have as their goal circulatory patency or the reversal of vascular … Continue reading →

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Stability and autolysis of cortical neurons in post-mortem adult rat brains

Posted on January 9, 2008 by Aschwin de Wolf

One scientific question that weighs heavily on the feasibility of contemporary cryonics is what happens to the brain after cardiac arrest. Common wisdom has it that the brain “dies” within 5-7 minutes after circulatory arrest. This is true in the … Continue reading →

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Systemic administration of L-Kynurenine

Posted on December 11, 2007 by Aschwin de Wolf

L-Kynurenine (L-KYN) is one of the neuroprotective agents used in cryonics stabilization protocol to limit injury to the brain after cardiac arrest. Administration of L-KYN was perceived to be essential to resuscitate dogs from extended periods (up to 17 minutes) … Continue reading →

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Human cryopreservation combinational pharmacotherapy

Posted on November 28, 2007 by Aschwin de Wolf

A comprehensive review of cryonics stabilization medications is now published on the Alcor website. Table of contents: * Introduction * General Anesthesia * Blood Coagulation * Vasoactive Medications * Excitotoxity * Free Radicals * Nitric Oxide and PARP * Inflammation … Continue reading →

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Fever and brain injury

Posted on November 26, 2007 by Chana de Wolf

Elevation of body temperature occurring as a result of hypothalamic coordination of autonomic, neuroendocrine, and behavioral responses in reaction to physiological injury or invasion is generally known as fever. Traditional thought is that the “febrile response” is beneficial in preventing … Continue reading →

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