Depressed Metabolism

One of the most neglected aspects of cryonics is that its procedures, and the research to support them, can have important practical applications in mainstream fields such as organ preservation and emergency medicine. Contrary to popular opinion, cryonics does not just involve an optimistic extrapolation of existing science but can set the standard for these [...]

Recent advances with the use of hydrogen sulfide, carbon monoxide and “hibernation induction triggers” to depress metabolism in animal models have  renewed interest  in the possibility of human hibernation.  The ability to drastically depress human metabolism without the use of cold (or in combination with cold) would have a number of important medical and scientific [...]

Japanese scientists have managed to clone a mouse that had been frozen without any cryoprotection for 16 years at minus 20 degrees Celsius. The researchers used the researchers used brain cell nuclei, and planted it into an egg of another living mouse, leading to the birth of the cloned mouse.
Although the objective of cryonics is [...]

This is the second in a series of interviews with individuals in the life extension and cryonics movement. The first interview was with Cryonics Institute president Ben Best. This interview is with Regina Pancake, Alcor’s Readiness Coordinator.
How did you get involved in cryonics?
My story is not your typical in the details, but in the overall [...]

The website TopTenz recently published a list of the Top 10 Most Famous Preserved Body Parts. The list includes Galileo’s finger and Albert Einstein’s brain. As has been discussed on this blog before, the preservation of human brains (no matter how frivolous the intention) raises a number of important questions about the nature of death [...]

My experiences with death began in 1974, when I was age 10.
On Labor Day Sunday, while watching the Jerry Lewis MDA telethon, my father told me to turn the TV off.
When I asked why, he said my grandfather, age 74, died.
I would learn years later that he had emphysema and heart trouble.
I did not know [...]

It has been shown that perfusability of the brain is significantly compromised after long-term (>5 min) ischemic events (the “no reflow” phenomenon). Improving cerebral blood flow after circulatory arrest is one of the fundamental objectives of human cryopreservation stabilization protocol.  To that end, cryonics organizations administer the resuscitation fluid Dextran-40 and the drug Streptokinase to [...]

Unless you are a long-time cryonicist or a surgeon, you may not have heard of BioTime before. This company, recently profiled for its innovative stem cell research in Life Extension Magazine, is best known for producing the blood-volume expander Hextend, which was initially developed by Trans Time, an early cryonics company performing ultra-profound hypothermia research. [...]

In 1991 the Libertarian Alliance published an article called “Immortality: Liberty’s Final frontier” (PDF) by David Nicholas. In this article the author argues that “the continuing fact of death renders all talk of liberty ultimately futile.” The author further argues that our concern for the future will diminish as we approach death. But instead of [...]

Rudi Hoffman, cryonics activist and the world’s leading cryonics insurance provider, is today’s featured guest on “The Future and You:”
“You can too take it with you!  How combining cryonics and insurance can let you leave your million dollar insurance death benefit to yourself. It may allow you to wake up a century or two in [...]

A PDF file of this article with images is available here.
“Tenderly you stroke a Nettle, and it stings you for your pains. Grasp it like a man of mettle, and it soft as silk remains.” – Old English proverb
Nearly 20 years ago Alan Sinclair successfully undertook to establish a cryonics facility in the UK. The [...]

In 2007, cryobiologist Armand M. Karow passed away. Unlike many contemporary cryobiologists, Karow offered cautious support for the objectives of cryonics. In the mid-1960s, Karow served on the Scientific Advisory Council of the Cryonics Societies of America (CSA). He also published a regular column titled “Scientifically Speaking” in Cryonics Reports, a publication by the Cryonics [...]

Can life exist without water? This is one of the questions that fascinates astrobiologists. The behavior of biomolecules in non-aqueous solutions is also of interest to cryobiologists and cryoenzymologists. Ice formation below zero degrees Celsius can be prevented by high concentrations of cryoprotective agents. But what are the effects of such vitrification agents on proteins?
In [...]

A PDF file of this document is available with images and structural visualization of various sugars.
D(+) lactose monohydrate is the principal sugar in mammalian milks. The monohydrate part is easiest to explain; it simply means that the lactose molecule has one water molecule attached to it. This is important because some chemicals can have a [...]

On August 23, Chana and Aschwin de Wolf drafted a blog entry on the phenomenon of partners who are hostile to cryonics. We sent our draft for review to a number of high profile cryonicists and received a message from Mike Darwin telling us that he still had an unpublished article on this topic. Because [...]

On September 6, 2007 we launched the blog Depressed Metabolism for a number of reasons. The most important one was to launch a blog with a strong emphasis on cryonics. Although there are a number of good blogs on aging and life extension, there was not such a blog for cryonics. Another reason was to [...]

Just a superficial look at the history of the life extension movement will suffice  to show the rise and fall of numerous fads and trends in ideas about the mechanisms and “treatment” of aging.  Psychological meliorism and simplistic visions of biochemistry create overly optimistic expectations about extending the maximum human lifespan.  But how can we [...]

Now online is an old interview with Robert W. Prehoda. Prehoda was a prolific science writer who published on topics such as aging, life extension, and technological forecasting. In 1969 Prehoda published the book “Suspended Animation: The Research Possibility That May Allow Man to Conquer the Limiting Chains of Time.” In this visionary book, Prehoda [...]

This is the first in a series of interviews with individuals in the life extension and cryonics movement. We start off with an interview with Ben Best, president of the Cryonics Institute.
What is your philosophy toward life?
I think that “sense of life” or emotional involvement  in life is the most crucial determinant of orientation [...]

On the Immortality Institute cryonics forum, Alcor Board member and researcher Brian Wowk has posted some insightful comments on the difference between suspended animation and cryonics. Although  impressive technical advances in cryonics to date, such as vitrification, have failed to translate into increased membership growth for cryonics organizations, many cryonics observers believe that demonstration of [...]

Now online is Mike Perry’s article “Historical Steps Toward the Scientific Conquest of Death.” This article was previously published in 2003 in Physical Immortality, a short-lived publication by the Society for Venturism.
The article is adapted from Chapter 2 of Mike Perry’s book, Forever For All: Moral Philosophy, Cryonics, and the Scientific Prospects for Immortality.

This book [...]

The blog dw2-0 reports on Mike Darwin’s recent ExtroBritannia talk in London:
“Mike Darwin made the same connection at an utterly engrossing UKTA meeting this weekend…. He spoke for over two hours, and continued in a formal Q&A session for another 30 minutes….
….The most poignant part was the description of the people issues during the [...]

James Bedford’s freezing in January 1967 is usually regarded as the first true cryonic suspension, done immediately after legal death under controlled conditions which, though primitive by today’s standards, may have opened the possibility of eventual reanimation. Yet there was an earlier freezing that, while more problematic from the standpoint of viability, was nonetheless important [...]

As mentioned in a previous contribution, Arthur C. Clark was no stranger to cryonics. The famous science fiction author once stated in a letter in support of cryonics, “Although no one can quantify the probability of cryonics working, I estimate it is at least 90% — and certainly nobody can say it is zero.”  And [...]

The two most popular technical arguments against human cryopreservation are that cryonics causes irreversible freezing damage and that the delay between pronouncement of legal death and the start of cryonics procedures causes irreversible injury to the brain. Such arguments can be countered by pointing out that freezing damage and prolonged periods of warm ischemia do [...]

In January 2008, Alcor’s self perpetuating Board came under renewed scrutiny after long-time Alcor member and cryonics activist David Pizer tried to raise interest for changing the current system to a member elected Board. Alcor’s most publicly visible response to the arguments raised by Pizer was to publish a document by Board member Ralph [...]

The following announcement from the Alcor Life Extension Foundation is indicative of its renewed focus on professionalizing the organization and improving the quality of readiness and patient care:
On June 7th and 8th, 2008, the Alcor board and management held a 2-day strategic planning meeting at the Alcor facility in Scottsdale, Arizona. At that meeting a [...]

An important objective during stabilization of cryonics patients is restoring circulation of blood to the brain. In ideal cases, this can be achieved by aggressive mechanical cardiopulmonary support, hemodilution ,and administration of vasoactive medications. In not-so-ideal cases, one or more of these interventions are omitted or delayed. This raises the question if low flow perfusion [...]

Let’s face it: we’re all (still) getting older, and aging leads to death. This is a major reason for cryonics’ existence — to preserve ourselves, usually in an aged, diseased, and/or deteriorated state, until medical science is capable of curing our ailments and prolonging our lives. Because many people (especially young cryonics supporters) tend to [...]