Cryonics Magazine- Scientists Eavesdrop Inside the Mind
- Discovery May Provide Insight into Brain Cell Aging
- New Evidence Keeping Brain Sharp and Active Wards off Alzheimer’s
- New Discoveries in Cell Aging
- Eye Trials Give Hope for Stem Cells
- How Stem Cell Implants Help Heal Traumatic Brain Injury
- Victory For Crowdsourced Biomolecule Design
- New Approach to Preventing Fatal Septic Shock
- Alzheimer’s Damage Occurs Early
- Oxidative DNA Damage Repair
- Fight Aging!
- Chronosphere
- Cryonics “Castle”
- Doing the Time Warp
- Interventive Gerontology 1.0.02: First, Try to Make it to the Mean: Diet as a life extending tool, Part 3
- Interventive Gerontology 1.0.02: First, Try to Make it to the Mean: Diet as a life extending tool, Part 2
- Interventive Gerontology 1.0.02: First, Try to Make it to the Mean: Diet as a life extending tool, Part 1.
- Fortune and Men’s Eyes
- Interventive Gerontology 101.01: The Basics
- The Kurzwild Man in the Night
- Fucked.
- You Bet Your Life!
Tag Archives: Cryobiology
Annotated bibliography of cryoprotectant toxicity
Introduction Cryoprotectant toxicity should be distinguished from other mechanisms of cryopreservation injury such as chilling injury (injury produced by too low temperatures as such) and cold shock (injury produced by rapid cooling). Cryoprotectant toxicity itself can again be divided into … Continue reading
Posted in Cryonics, Science
Tagged Brian Wowk, Cryobiology, Cryoprotectant Toxicity, DMSO, Ethylene Glycol, Glycerol, Gregory Fahy, Vitrification
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The 2011 Cryobiology Conference
July 24-27 I attended the 2011 annual Society for Cryobiology conference in Corvallis, Oregon. A number of the first presentations were concerned with means to *avoid* cryopreservation. Room temperature storage is much less expensive and troublesome, and improves ease of … Continue reading
Posted in Cryonics, Science
Tagged Arthur Rowe, Chilling Injury, Cryobiology, John Crowe, Microtubules, Peter Mazur, Society for Cryobiology Conference
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Gerald Feinberg on physics and life extension
Gerald Feinberg, a Columbia university physicist who, among other things, hypothesized the existence of the muon neutrino, had a strong interest in the future of science and life extension. In 1966 he published the article “Physics and Life Prolongation” in … Continue reading
Posted in Cryonics
Tagged Brain Repair, Cryobiology, Cryonics, Foresight Institute, Gerald Feinberg, Molecular Nanotechnology
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Neural cryobiology and the legal recognition of cryonics
It has been said that if you want to persuade someone, you need to find common ground. But one of the defining characteristics of cryonics is that proponents and opponents cannot even seem to agree on the criteria that should … Continue reading
Posted in Cryonics, Death, Neuroscience
Tagged B2C, Brain Death, Brian Wowk, Cryobiology, Cryonics, EEG, Gregory Fahy, Information-theoretic Death, M22, Neural Cryobiology, Neuroscience, Robert J. White, Yuri Pichugin
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At last, a sure-cold way to sell cryonics with guaranteed success!
A humorous romp through a promising new technique in aesthetic medicine from one cryonicist’s (warped) point of view. Figure 1: Before cryopreservation (L) and after cryopreservation (R). As everyone involved in cryonics for more than a fortnight is sadly aware, … Continue reading
Posted in Cryonics, Health, Science
Tagged Adipocytes, Chilling Injury, Cosmetic Surgery, Cryobiology, Cryolipolysis, Cryonics, Hypothermia, Mike Darwin, Organ Preservation, Zeltiq
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Ben Best on the feasibility of cryonics at SENS3
Posted in Cryonics, Death, Science
Tagged Arrhenius Equation, Ben Best, Cerebral Ischemia, Cryobiology, Cryonics, Death, Peter Safar, Rejuvenation, SENS, Vitrification
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Robert Ettinger on cryonics and research
One of the most common criticisms of cryonics is to argue that cryonics can only be a legitimate endeavor when there is (peer reviewed) demonstration of whole body suspended animation. Advocates of cryonics point out that this is an unreasonable … Continue reading
Posted in Cryonics
Tagged Cryobiology, Cryonics, Long-Term Potentiation, Research, Robert Ettinger, Suspended Animation
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The case for cryonics
The biology-of-aging blog Ouroboros has posted a skeptical post about cryonics that is highly representative of how most biological scientists respond to questions about cryonics. The discussion of cryonics is largely reduced to a discussion of the technical feasibility of … Continue reading
Posted in Cryonics, Society
Tagged Aging, Bio-nanotechnology, Biogerontology, Cryobiology, Cryonics, Decision Theory, Ouroboros, Pascal's Wager, Rational Choice, Rejuvenation, Science
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Cryonics in the media
The Detroit News features a story about cryonics that is a good illustration of the upward battle that cryonics faces in the media. First and foremost, this story reinforces the idea that cryonics concerns the practice of freezing dead people: … Continue reading
The pursuit of cryonics as medicine
The biggest obstacle to the acceptance of cryonics is medical myopia; the idea that someone who has been pronounced dead by contemporary medical criteria will still be considered dead by future criteria. Advocates of human cryopreservation strongly argue against this. … Continue reading
Posted in Cryonics
Tagged Alcor, Bioethics, Critical Care Medicine, Cryobiology, Cryonics, Jerry Leaf, Medical Myopia, Medicine, Mike Darwin, Nanotechnology, Synthetic Biology, Vitrification
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Reversible cryopreservation
On the forum of the Immortality Institute there is an interesting exchange about the feasibility and time line for reversible cryopreservation. Cryobiologist Brian Wowk weighs in with some interesting observations: I think in the next 20 years more small animal … Continue reading
Posted in Cryonics
Tagged Brain Cryopreservation, Brian Wowk, Cryobiology, Cryonics, Ischemia, Nanotechnology, Vitrification
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The future of Alcor
Alcor’s recent news item about its 2009 Annual Board Meeting and Strategic Meeting contains a number of encouraging statements. On the front of institutional reform, however, there is not much news to report. The passage about the need to balance … Continue reading
Posted in Cryonics
Tagged Alcor, Cryobiology, CryoCare, Cryonics, Cryonics FAQ, Cryonics Institute, Medicine, Perfusion, Salaries
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The 2009 SENS Conference
Once a year I try to attend at least one biogerontology conference. Although I attend biogerontology conferences out of personal interest, and at my own expense, they are the most fruitful grounds for promoting cryonics I have found, and this … Continue reading
Posted in Cryonics, Science
Tagged Aubrey de Grey, Ben Best, Cryobiology, Cryonics, Cryonics Institute, Cryoprotectant Toxicity, KrioRus, SENS
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Basile J. Luyet on the instability of solidified solutions
Basile J. Luyet (1897-1974) can be considered the father of modern cryobiology. His book “Life and Death at Low Temperatures” is a classic in the field and his journal “Biodynamica” evolved into a publication solely dedicated to the study of … Continue reading
Posted in Cryonics, Science
Tagged Basile J. Luyet, Ben Best, Cryobiology, Cryonics, De-vitrification, Greg Fahy, Intermediate Temperature Storage, Low Temperature Biology, Vitrification
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5 dangerous ideas about cryonics
The cryonics organizations Alcor and the Cryonics Institute have taken great care to correct some of the persistent myths about cryonics. With so much widespread misinformation being circulated in the media it seems trivial to pay attention to some of … Continue reading
Posted in Cryonics, Death
Tagged Brian Wowk, Cryobiology, Cryonics, Human Cryopreservation, Thomas Donaldson
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The red blood cell as a model for cryoprotectant toxicity
Various approaches are available to investigate cryoprotectant toxicity, ranging from theoretical work in organic chemistry to cryopreservation of complete animals. Because resuscitation of complex organisms after cryopreservation is not feasible at the moment, such investigations need to be confined to … Continue reading
Posted in Health, Science
Tagged Cryobiology, Cryoenzymology, Cryoprotectant Toxicity, Erythrocytes, Red Blood Cells, Vitrification
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Robert White on brain death
Robert J. White is most known, or perhaps most notorious, for his work on primate head transplants. Less known, but more relevant to the practice of human cryopreservation, is his work in cerebral ischemia, hypothermia, and brain preservation. Most of … Continue reading
Posted in Cryonics, Death, Neuroscience
Tagged Brain Death, Cryobiology, Cryonics, Robert J. White
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Cloning of frozen mice and cryonics
Japanese scientists have managed to clone a mouse that had been frozen without any cryoprotection for 16 years at minus 20 degrees Celsius. The researchers used the researchers used brain cell nuclei, and planted it into an egg of another … Continue reading
Armand Karow on Isamu Suda’s brain cryopreservation experiments
In 2007, cryobiologist Armand M. Karow passed away. Unlike many contemporary cryobiologists, Karow offered cautious support for the objectives of cryonics. In the mid-1960s, Karow served on the Scientific Advisory Council of the Cryonics Societies of America (CSA). He also … Continue reading
Posted in Cryonics, Neuroscience
Tagged Armand M. Karow, Brain Cryopreservation, Cryobiology, Cryonics, Isamu Suda, Meliorism
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Greg Fahy on the cryopharmacology of vitrification solutions
In an abstract in Cryobiology 55 (2007), 21st Century Medicine researcher Greg Fahy reports on the biological (pharmacological or “cryopharmacological”) effects of vitrification solutions. He identifies four different mechanisms of toxicity: 1. “Specific toxicity,” or the effects of vitrification agents … Continue reading
Life in non-aqueous solutions
Can life exist without water? This is one of the questions that fascinates astrobiologists. The behavior of biomolecules in non-aqueous solutions is also of interest to cryobiologists and cryoenzymologists. Ice formation below zero degrees Celsius can be prevented by high … Continue reading
Posted in Cryonics, Science
Tagged Astrobiology, Cryobiology, Cryonics, Cryoprotectant Toxicity, Enzymology, Extremophiles, Suspended Animation
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Cryoenzymology and cryoprotectant toxicity
The major limiting obstacle to reversible cryopreservation of complex organs is cryoprotectant toxicity. Elimination of ice formation through vitrification requires high concentrations of cryoprotective agents. These high concentrations of cryoprotectants can be toxic to tissues. Over the years, major advances … Continue reading
Posted in Cryonics, Science
Tagged Astrobiology, Cryobiology, Cryoenzymology, Extremophiles, Vitrification
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Robert Prehoda in Cryonics Reports
Now online is an old interview with Robert W. Prehoda. Prehoda was a prolific science writer who published on topics such as aging, life extension, and technological forecasting. In 1969 Prehoda published the book “Suspended Animation: The Research Possibility That … Continue reading
Posted in Cryonics
Tagged Cryobiology, Cryonics, Life Extension, Robert Prehoda, Suspended Animation
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Philip Ball on water in biology
Philip Ball, author of “Life’s Matrix: A Biography of Water”, and publisher of the excellent blog, Water in Biology, reports on recent papers about the interaction of water and bio-molecules, including a recent study on trehalose: H. Nagase of Hoshi … Continue reading
Vitrification agents in cryonics
Today’s post on 21st Century Medicine’s vitrification agent M22 completes the series on vitrification agents in cryonics. To date, three different vitrification agents have been used for cryopreservation of humans: B2C (at Alcor from 2001-2005), VM-1 (at the Cryonics Institute … Continue reading
Posted in Cryonics
Tagged Alcor, Cryobiology, Cryonics, Cryonics Institute, Vitrification
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Cryoprotectant toxicity: biochemical or osmotic?
The current generation of vitrification agents in cryonics permit elimination of ice formation using realistic cooling rates. But attempts to vitrify the brain require high concentrations of cryoprotective agents to inhibit ice formation. Such high concentrations of cryoprotectants can produce … Continue reading
Posted in Cryonics
Tagged Cryobiology, Cryonics, Cryoprotectant Toxicity, Vitrification
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Viability in brain cryopreservation
Because the current generation of vitrification agents permit cryopreservation of the brain without ice formation, the current objective of cryonics research is maintenance of viability of the brain during cryopreservation. The most popular viability assay that has been used in … Continue reading
Posted in Cryonics, Neuroscience
Tagged 21st Century Medicine, Cryobiology, Cryonics, Cryopreservation, Memory, Viability Assays, Vitrification
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Ben Best publishes on cryonics in Rejuvenation Research
A technical cryonics article to be published in the conference proceedings of a customarily peer-reviewed scientific journal, entitled “Scientific Justification of Cryonics Practice (pdf),” by Ben Best, President of the Cryonics Institute, will appear in the next issue (Volume 11, … Continue reading
Posted in Cryonics, Science
Tagged Ben Best, Cryobiology, Cryonics, Rejuvenation, Vitrification
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Characterization of afterhyperpolarization (AHP) in cryopreserved brain slices
An ongoing quest in cryonics is the successful demonstration of memory sustainment after cryopreservation of the brain and rewarming from cryogenic temperatures. To that end, landmark experiments were performed by Pichugin, et al. (2006) on rat hippocampal brain slices which … Continue reading
Posted in Cryonics, Neuroscience
Tagged Brain, Brain Slice, Cryobiology, Hippocampus, Memory, Viability
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