Tag Archives: Cerebral Ischemia

Alcor member profile of Aschwin de Wolf

Posted on August 18, 2011 by Aschwin de Wolf

The latest issue of Cryonics magazine features my member profile. This profile was written by Cairn Idun, a long-time Alcor member and cryonics activist who is currently known for organizing the annual asset preservation and teens and twenties meetings. To … Continue reading →

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How many neurons need to survive for cryonics to work?

Posted on July 27, 2010 by Aschwin de Wolf

On this page a calculation is attempted to determine how many neurons need to survive for cryonics to work. The flaw in this approach should be obvious when the author writes : According to The Stroke Association, a stroke is … Continue reading →

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Ben Best on the feasibility of cryonics at SENS3

Posted on February 26, 2010 by Aschwin de Wolf
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No-reflow as a post-mortem artifact

Posted on May 4, 2009 by Aschwin de Wolf

It is common medical knowledge that after 5 minutes of cardiac arrest the prospects of successful resuscitation without neurological impairment become progressively bleak. But there is less consensus on the mechanisms of such injury. One strong candidate is what is … Continue reading →

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Microvasculature perfusion failure in cryonics

Posted on February 23, 2009 by Aschwin de Wolf

Under ideal circumstances cryonics patients are stabilized immediately after pronouncement of legal death by restoring  blood flow to the brain, lowering temperature, and administering medications. In most cryonics cases, however, there is a delay between pronouncement of legal death and … Continue reading →

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Promoting cerebral blood flow in cryonics patients

Posted on October 17, 2008 by Chana de Wolf

It has been shown that perfusability of the brain is significantly compromised after long-term (>5 min) ischemic events (the “no reflow” phenomenon). Improving cerebral blood flow after circulatory arrest is one of the fundamental objectives of human cryopreservation stabilization protocol.  … Continue reading →

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Structure-function analysis of neuroprotectants

Posted on August 31, 2008 by Mike Darwin

In “The chemistry of neuroprotection”, the author argues convincingly that there could be great benefit from a systematic and rigorously scientific study of the physical chemistry of putative neuroprotectants vis-à-vis their pharmacological effect. However, the first example used of the … Continue reading →

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The chemistry of neuroprotection

Posted on August 25, 2008 by Aschwin de Wolf

In a review of the 1998 21st Century Medicine seminars, Cryonics Institute president Ben Best writes: “The presentations impressed upon me how much witchcraft and how little science has gone into the study of cryoprotectant agents (CPAs). This might be … Continue reading →

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Incomplete ischemia during cardiopulmonary support

Posted on July 17, 2008 by Aschwin de Wolf

One concern about prolonged cardiopulmonary support in cryonics is that its decreasing effectiveness may not be able to meet cerebral oxygen demand, and may even become detrimental. Some investigators have  observed that severely reduced flow (cerebral blood flow less than 10% of … Continue reading →

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Critical cooling rate to prevent ischemic brain injury

Posted on July 10, 2008 by Aschwin de Wolf

Induction of hypothermia can reduce injury to the brain when it is deprived of oxygen. How fast do we need to cool a patient during cardiac arrest or stroke to prevent irreversible injury to the brain? It is an established … Continue reading →

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Polyethylene glycol and cryonics

Posted on June 30, 2008 by Aschwin de Wolf

The blog Al Fin reports on polyethylene glycol (PEG) as an acute treatment for traumatic brain and spinal cord injury. PEG is hypothesized to confer cytoprotection by sealing damaged cell membranes. As such, PEG would also seem a promising candidate … Continue reading →

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Wide therapeutic window for melatonin in stroke

Posted on June 5, 2008 by Chana de Wolf

Neuroprotective agents for stroke continue to fail in clinical trials. One important reason is that the therapeutic window for many of those agents is too narrow to confer benefits to acute stroke victims. It would be desirable to have a … Continue reading →

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