Depressed Metabolism

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More than a decade of basic research and clinical evidence now implicates inflammatory processes in the pathogenesis of Alzheimer’s disease (AD). TNF-alpha is a pro-inflammatory cytokine, also known as the “master regulator” of the immune response, and is the key initiator of immune-related inflammation in the brain. Much evidence has linked excess TNF-alpha to the [...]

The latest issue of Life Extension Magazine (August 2008) contains an encouraging report about off-label use of etanercept (commercial name: Enbrel) to reverse the cognitive deficits associated with Alzheimer’s disease. Etanercept is a tumor necrosis factor (TNF) blocker that is used to treat diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, and [...]