Depressed Metabolism

Although critical philosophers like Herbert Marcuse (1898 – 1979) are not known for their contributions to economics or analytical philosophy, Marcuse’s essay “The Ideology of Death” (1952) should appeal to those who think that death is not a necessary part of existence, let alone something to celebrate. In this essay, the author discusses the phenomenon [...]

The blog Soft Machines writes about a new opinion piece in the Financial Times by David Shaywitz and Nassim Nicholas Taleb on biomedical science and drug discovery. The molecular revolution in biology was supposed to substitute rational design of drugs for trial and error and handwaving. So why do pharmaceutical companies have so little to [...]

Despite sensational news items about “zombie dogs,” biomedical researchers and clinicians have known for a long time that interruptions in consciousness and blood circulation can be reversed without neurological deficits, provided such events do not produce ischemic injury. There are even species who can enter a state of reversible metabolic arrest such as tardigrades (water [...]

More than a decade of basic research and clinical evidence now implicates inflammatory processes in the pathogenesis of Alzheimer’s disease (AD). TNF-alpha is a pro-inflammatory cytokine, also known as the “master regulator” of the immune response, and is the key initiator of immune-related inflammation in the brain. Much evidence has linked excess TNF-alpha to the [...]

BLDGBLOG reports on Mysterious Chinese Tunnels:
“Zimmerman claims that “mysterious” tunnels honeycombed the ground beneath the city of Tacoma, Washington…It’s like a geography purpose-built for H.P. Lovecraft, or something straight out of the work of Jeff VanderMeer: down in the foundations of your city is a mysterious network of rooms, excavated by another race, through which [...]

In a recent blog post, Overcoming Bias reports that Gary Taubes, who has written much to further the idea that refined carbohydrates are a stronger contributing factor to overweight and “diseases of civilization” than dietary fat and cholesterol, has compiled his thoughts on the subject in a major 600-page work called Good Calories, Bad Calories.
Why [...]

The two most popular technical arguments against human cryopreservation are that cryonics causes irreversible freezing damage and that the delay between pronouncement of legal death and the start of cryonics procedures causes irreversible injury to the brain. Such arguments can be countered by pointing out that freezing damage and prolonged periods of warm ischemia do [...]

In January 2008, Alcor’s self perpetuating Board came under renewed scrutiny after long-time Alcor member and cryonics activist David Pizer tried to raise interest for changing the current system to a member elected Board. Alcor’s most publicly visible response to the arguments raised by Pizer was to publish a document by Board member Ralph [...]

The following announcement from the Alcor Life Extension Foundation is indicative of its renewed focus on professionalizing the organization and improving the quality of readiness and patient care:
On June 7th and 8th, 2008, the Alcor board and management held a 2-day strategic planning meeting at the Alcor facility in Scottsdale, Arizona. At that meeting a [...]

As Americans increasingly feel the pain of long-distance commuting, economic ignorance of politicians combines with our perceived inalienable right to low gas prices to find a scapegoat in the world’s most hated minority in bad economic times, the speculator.
As the economist and political philosopher Anthony de Jasay recently pointed out, politicians seem to believe that [...]

An important objective during stabilization of cryonics patients is restoring circulation of blood to the brain. In ideal cases, this can be achieved by aggressive mechanical cardiopulmonary support, hemodilution ,and administration of vasoactive medications. In not-so-ideal cases, one or more of these interventions are omitted or delayed. This raises the question if low flow perfusion [...]

Let’s face it: we’re all (still) getting older, and aging leads to death. This is a major reason for cryonics’ existence — to preserve ourselves, usually in an aged, diseased, and/or deteriorated state, until medical science is capable of curing our ailments and prolonging our lives. Because many people (especially young cryonics supporters) tend to [...]

It is difficult to match concerns about reperfusion injury during cardiopulmonary resuscitation (CPR) with specific proposals for alternative interventions. After all, no matter how harmful the effects of oxygenation may be, not restoring circulation in a patient in cardiac arrest is hardly a credible option. One alternative would be to restore circulation but withhold oxygen [...]

One concern about prolonged cardiopulmonary support in cryonics is that its decreasing effectiveness may not be able to meet cerebral oxygen demand, and may even become detrimental. Some investigators have  observed that severely reduced flow (cerebral blood flow less than 10% of control) to the brain may actually be more harmful than no flow at all.  Explanations [...]

From: ExtroBritannia
Cryonics: Why it has failed, and possible ways to fix it – with Mike Darwin
The next ExtroBritannia event is scheduled for Saturday August 2, 2008; 2:00pm – 4:00pm.
Location to be announced asap.
Lead Speaker: Mike Darwin, President of Alcor Life Extension 1983-1988, Research Director 1988-1992. Described by Wikipedia as “Second only to Robert Ettinger [...]

Most life extensionists and transhumanists do not buy into many of the myths about cryonics. But one perspective that is sometimes voiced by futurists is that cryonics is a rational backup plan until aging is cured. This position has some serious shortcomings and potentially lethal implications.
Human cryopreservation is the practice of placing terminally ill patients [...]

The latest issue of Life Extension Magazine (August 2008) contains an encouraging report about off-label use of etanercept (commercial name: Enbrel) to reverse the cognitive deficits associated with Alzheimer’s disease. Etanercept is a tumor necrosis factor (TNF) blocker that is used to treat diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, and [...]

One problem in assessing the merits of taking a specific dietary supplement (ranging from vitamins to  exotic multi-ingredient compounds) is widespread selection bias in the documentation that is supposed to support the use of the supplement in question.  The sheer number of scientific studies combined with variation in research methodologies virtually guarantees that for every [...]

Induction of hypothermia can reduce injury to the brain when it is deprived of oxygen. How fast do we need to cool a patient during cardiac arrest or stroke to prevent irreversible injury to the brain?
It is an established fact that induction of hypothermia prior, during, or after circulatory arrest can reduce brain injury. As [...]

Economic illiteracy and the human bias to look for a scapegoat conspire to single out speculators in oil futures as the reason for high oil prices.  Exploiting this ignorance about economics, airline executives call on Congress to curb excessive speculation in one of the most blatant examples of corporate socialism in recent history. What is [...]

Today’s post on 21st Century Medicine’s vitrification agent M22 completes the series on vitrification agents in cryonics. To date, three different vitrification agents have been used for cryopreservation of humans: B2C (at Alcor from 2001-2005), VM-1 (at the Cryonics Institute since 2005) and M22  (at Alcor since 2005).
Perhaps the most encouraging development in cryonics is [...]

M22 represents the culmination of decades of work in applied cryobiology by researchers Gregory Fahy , Brian Wowk, and others to develop a vitrification agent that can recover complex organs (such as the kidney) from cryogenic temperatures without ice formation and minimal toxicity. In 2005, M22 was licensed by the patent holder 21st Century Medicine [...]

How do you teach a child about something that is so far “unproven”?  How do you bring up the subject of cryonics and how it may allow someone to be reanimated in the future?
I am a cryonicist, I’ve been a signed member for years, I’m also a mother, social activist, environmentalist and author.  I teach [...]

“The only thing that retards aging is calorie restriction. As genetic studies go forward, we’ll find out why.” Roy Walford
Our society in America currently as of 2008 has more overweight people than average-weight people.  ‘Healthy weight’ Americans consist of only around 40% of the population, according to the US Center for Disease Control and Prevention, [...]

“Do not train a child to learn by force or harshness; but direct them to it by what amuses their minds, so that you may be better able to discover with accuracy the peculiar bent of the genius of each.” Plato (BC 427-BC 347) Greek philosopher.
Of course, children are the future. Some children are planned, [...]

Over the next three days Shannon Vyff will be guest blogging for Depressed Metabolism. Shannon Vyff is a practicing caloric restrictionist, Alcor member, and Methuselah Foundation supporter. Shannon also volunteers for her local Unitarian Universalist Church and La Leche League group.  She lives with her three children Avianna, Avryn, and Avalyse, and husband Michael (all [...]